Two sample MR report
GRHPR_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0448688 | 0.1461277 | 0.8103421 |
| Weighted median | 3 | 0.0246279 | 0.0127807 | 0.0539843 |
| Inverse variance weighted | 3 | 0.0227155 | 0.0109216 | 0.0375378 |
| Simple mode | 3 | 0.0268633 | 0.0141718 | 0.1984914 |
| Weighted mode | 3 | 0.0268271 | 0.0152590 | 0.2208029 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0000001 | 1 | 0.9997370 |
| Inverse variance weighted | 0.2151094 | 2 | 0.8980274 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0450252 | 0.0970792 | 0.7235354 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.24e-05 | 0 | TRUE | 0.5893376 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
